Metformin and Sitagliptin: Dual Therapy for Type 2 Diabetes Management

The combination of metformin and sitagliptin is a widely used oral treatment for controlling high blood sugar in patients with type 2 diabetes. Metformin works by decreasing glucose absorption in the intestines, limiting glucose production in the liver, and enhancing insulin sensitivity in body tissues. Sitagliptin complements this action by boosting the body’s natural incretin levels, encouraging the pancreas to release more insulin and reducing hepatic glucose output when blood sugar is elevated. This drug combination is not intended for individuals with type 1 diabetes or those requiring insulin therapy.