{"product_id":"isordil-10mg-isosorbide-dinitrate-1","title":"ISORDIL  10mg (Isosorbide Dinitrate)","description":"\u003cp\u003e\u003cstrong\u003eDescription:\u003c\/strong\u003e\u003cbr\u003eISORDIL (Isosorbide Dinitrate) is a nitrate medication used primarily to prevent and manage \u003cstrong\u003eangina pectoris\u003c\/strong\u003e (chest pain) caused by coronary artery disease. It works by relaxing and dilating blood vessels, reducing the heart's workload and improving oxygen delivery to the heart muscle.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMechanism of Action:\u003c\/strong\u003e\u003cbr\u003eIsosorbide dinitrate is converted into nitric oxide, which activates guanylate cyclase, leading to an increase in cyclic GMP. This process relaxes vascular smooth muscle, resulting in \u003cstrong\u003evasodilation\u003c\/strong\u003e (widening of blood vessels). The primary effects include reduced \u003cstrong\u003emyocardial oxygen demand\u003c\/strong\u003e and improved \u003cstrong\u003ecoronary blood flow\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIndications:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ePrevention of angina attacks\u003c\/li\u003e\n\u003cli\u003eManagement of chronic heart failure (as part of combination therapy)\u003c\/li\u003e\n\u003cli\u003eOff-label use in pulmonary hypertension\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eDosage \u0026amp; Administration:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eTypically taken \u003cstrong\u003esublingually (under the tongue)\u003c\/strong\u003e or orally, depending on the formulation\u003c\/li\u003e\n\u003cli\u003eMust follow a \u003cstrong\u003enitrate-free interval\u003c\/strong\u003e to prevent \u003cstrong\u003etolerance\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eCommon Side Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eHeadache\u003c\/li\u003e\n\u003cli\u003eDizziness\u003c\/li\u003e\n\u003cli\u003eHypotension (low blood pressure)\u003c\/li\u003e\n\u003cli\u003eFlushing\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eContraindications \u0026amp; Precautions:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eShould \u003cstrong\u003enot\u003c\/strong\u003e be used with \u003cstrong\u003ephosphodiesterase-5 (PDE-5) inhibitors\u003c\/strong\u003e (e.g., sildenafil\/Viagra) due to the risk of severe hypotension\u003c\/li\u003e\n\u003cli\u003eCaution in patients with \u003cstrong\u003esevere anemia, hypotension, or increased intracranial pressure\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Zuellig Pharma","offers":[{"title":"10 mg Tablet 1's","offer_id":48942569259145,"sku":"202503022046","price":26.0,"currency_code":"USD","in_stock":true},{"title":"10 mg Tablet 100's","offer_id":48942569291913,"sku":"202503022047","price":2600.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0789\/6550\/6185\/files\/Isordil_10mgTablet1_grande_de2643ac-fa5a-4ef4-b7d7-c21f9d681657.webp?v=1794275594","url":"https:\/\/shoplumvella.shop\/products\/isordil-10mg-isosorbide-dinitrate-1","provider":"Elmwood Trading","version":"1.0","type":"link"}